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Methods A total of 38 participants (21 obese and 17 nonobese controls) were recruited for this study

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In addition, the incubation the neuron cell lines with LLP-1 induced a decrease in GSH levels, mitochondrial membrane depolarization, and H 2 O 2 production rapidly

In vitro assays demonstrated that FSP1-knockout cells show heightened sensitivity to GPx4 inhibitors, further validating FSP1 as a key component of the ferroptosis defense system (103)

244 Berberine alleviates diabetes-induced pain by inhibiting transient receptor potential vanilloid 1 (TRPV1) and the PKC pathway, reducing inflammation (Fig

Jazani et al., 2019